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Alimentary Pharmacology and Therapeutics 38, 255263

179 GueganC.VilaM.RosoklijaG.HaysA

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Multiple randomised trials from the 1970s and 1980s have shown its antiparkinsonian efficacy while its antidyskinetic efficacy in PD patients with LIDs was only demonstrated some 30 years after its introduction into PD therapy [13]

Toxicol Sci 59:169177 Fisher ES, Curry SC (2019) Evaluation and treatment of acetaminophen toxicity

An example of an NO prodrug is O 2 -(2,4-dinitrophenyl)1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K), devised by Keefer et al from the National Cancer Institute