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Neutrophils were stimulated with LPS (10 g ml 1 ), PMA (100 nM), A23187 (1.25 M) or crosslinking CD16 (2.4G2, 553142, BD) with a secondary goat anti-rat IgG (112-005-062, Jackson ImmunoResearch)

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In general, an increase in the pH weakens the hydrophobic interaction probably due to an increased titration of charged groups, thereby leading to an increase of protein hydrophilicity

Reconstituted Storage With bacteriostatic water, refrigerate at 28C, protected from light, use within 28 days

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This 'first-pass effect' exposes the compound to hepatic enzymes