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doi: 10.4103/ajprhc.ajprhc_88_24 182

Specifically, -Syn exposure suppressed components of the IL-6 signal transducer (IL6ST)/JAK2/STAT3/hypoxia-inducible factor 1 subunit (HIF-1) axis and promoted marked upregulation of multiple ferroptosis-related genes, including transferrin receptor (TFRC), ChaC glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1), nuclear factor, erythroid 2like 2 (NFE2L2, most commonly known as Nrf2), ferritin heavy chain 1 (FTH1), glutathione peroxidase 4 (GPX4), and HSP B (small) member 1 (HSPB1)

10.1016/j.reprotox.2003.10.006 135 van den DriescheS.KilcoyneK

doi: 10.1128/aac.03046-15 144 GuoY.XuM.ZhangJ.MaZ.CuiJ.ZhaoL.et al

Chow, R., Chiu, L., Navari, R., Passik, S., Chiu, N., Popovic, M., & Herrstedt, J

Observational evidence suggests the risk of cardiovascular disease doubles for each increment of 20 mm Hg systolic and 10 mm Hg diastolic above 115/75 mm Hg