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(2000) showed that high concentrations (1.5 mM) of the NO donors S -nitroso- N -acetyl-penicillamine (SNAP) and (Z)1-[N-93-ammonio-propyl-N-(n-propyl)amino] diazen-1-ium-1,2 diolate (PAPA/NO) exacerbated tumor necrosis factor alpha (TNF-) induced cardiac dysfunction and cellular injury in both isolated rat hearts (Langendorff model) and cultured cardiomyocytes 43

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More clinically applicable GGT-targeted probes for visualizing deep cancer need further studies, which may contribute to the early diagnosis of clinical tumors

Because the inclusion of these covariates did not alter effect estimates materially we did not include them in the final models

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