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In a Japanese population, the C677T allele frequency was very high, and the frequency of homozygous genotypes was 11% [11]

L., Kraus A., Megerle K., Pham H., Chang J

Exposure to toxins, alcohol, and stress can deplete glutathione levels, leading to sluggish detoxification

Perinatal cytomegalovirus (CMV) infection has been suggested to be a possible cause or trigger of BA, in that CMV infection initiates damage to the bile duct, which is then followed by autoimmune responses targeting the bile duct