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For example, -KG supplementation significantly reduced hepatic gluconeogenesis and ameliorated hyperglycemia [31]

LtxA affects the kidney mainly by acting on white blood cells to produce an immune response

Acute toxicity studies in animals, if extrapolated to humans, implicate a single dose of 10-15 grams necessary to produce significant liver toxicity, although several human case reports have shown toxicity at doses less than 4 grams per day (likely due to having one or more risk factors for sensitivity to toxicity) (Amar 2007)