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470 One could argue that the success of sodium-glucose cotransporter 2 (SGLT2) inhibitors, and now of GLP-1RAs, suggests that metabolic abnormalities play an important role in driving HFpEF

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doi: 10.1016/s0165-0327(02)00426-3 39 KimT

The principal genetic causes of AD are mutations in different genes, such as APP (Goate et al., 1991), -secretase proteins presenilin-1 and presenilin-2 (PSEN1-2) (Scheuner et al., 1996), which result in the production of aggregation-prone A peptides, called oligomers

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