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While several studies have demonstrated that anti-inflammatory therapies improve cardiac function and structure in preclinical and preliminary clinical settings, large randomized clinical trials have not been conducted in patients with HF, particularly those with HFrEF [41]

Subacute combined degeneration of the spinal cord

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Malnutrition or malabsorption causes decreased insulin signaling which reduces GHR expression and blocks the GH signaling pathway leading to IGF-I expression (GHR uncoupling), while GHs metabolic actions on lipolysis and gluconeogenesis are unaffected

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Ann Intern Med , 2012 Nov 13