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Although the degree of inflammation in OA is generally lower than in rheumatoid arthritis, synovial tissue can still exhibit marked hyperplasia and inflammatory cell infiltration ( Accompanying inflammation and mechanical damage, oxidative stress and multiple forms of cell death are deeply involved in the molecular mechanisms driving OA progression ( Figure 1 )

10.1530/JME-19-0153 79 CrespoM

Increasing the number of pharmacological/therapeutic targets of the anti-ulcer, cytoprotective stable gastric pentadecapeptide BPC 157

202 Thus, natural products may serve as an additional resource for the discovery of new GPX4 inhibitors

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