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Bilirubin metabolism Excess bilirubin causes jaundice Bilirubin is the catabolic product of heme

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In various acute and chronic liver injury models in mice, IL-22 has been shown to reduce hepatocyte damage and enhance liver regeneration by upregulating the expression of antioxidant and anti-apoptotic genes, such as heme oxygenase-1 (HO-1) and B-cell lymphoma-extra large (Bcl-xL) [151]

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