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Overall, this highlights the primary-origin influence and brain-adaptation signaling that shape BrM biology and formation

Foreign sites dominate inspections Interestingly, more than 62% of FDA drug quality inspections in FY2024 targeted foreign manufacturing sites , a trend that continued directly into FDA warning letters 2025

Small number of research groups : A limited number of research groups have conducted most studies, which may affect the generalizability of the results

Cell 109(3):307320