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Selenium and Milk Thistle: These compounds may support the liver and enhance detoxification processes

The relationship is tripartite: Selenium Selenocysteine Glutathione Peroxidase (GPx) HO Neutralization Requires Glutathione (GSH) as substrate Selenium provides the enzymatic machinery

Kumar G, Dey SK, Kundu S (2020) Functional implications of vascular endothelium in regulation of endothelial nitric oxide synthesis to control blood pressure and cardiac functions

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This suggests that risperidone's metabolic side effects are largely driven by changes in gut microbes, opening up the possibility of targeting the microbiome to prevent or reduce weight gain in patients taking this medication