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Interestingly, down-regulation of immediate early genes, altered synaptic signaling, an anxiety-like behavior, and mild neuronal loss have been observed in these transgenic mice, suggesting that increased TMEM106B levels negatively impact brain health [199]

Together, they provide researchers with tools to explore receptor-mediated signaling and downstream experimental readouts in controlled models

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Subcutaneous fat and lean mass were preserved or modestly improved

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