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[76] The presence of such metals in biological systems in an uncomplexed form (not in a protein or other protective metal complex) can significantly increase the level of oxidative stress

Image courtesy of Lexi Vu in the Pyeon lab at Michigan State University

Rayner KJ, Sheedy FJ, Esau CC, Hussain FN, Temel RE, Parathath S, van Gils JM, Rayner AJ, Chang AN, Suarez Y, Fernandez-Hernando C, Fisher EA, Moore KJ

These serological abnormalities are not isolated findings but are connected to broader physiological disruptions, including liver function, which is crucial in iron metabolism (209)

Advanced/Metastatic CRC - Targeted Therapies in CRC

3.2.2 TRAP A key advantage of this assay is its sensitivity to all known chain-breaking antioxidants, with established clinical correlations in various disease states (Prior et al., 2005)