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[DOI] [PubMed] [Google Scholar] 414.Xu KY, Zweier JL, Becker LC

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Maintaining muscle function across the lifespan: the state of science

A: It can cause mild water retention in some patients, usually noticed as slight swelling in the fingers or ankles

The question that longevity researchers are actively investigating is whether restoring NAD+ levels can meaningfully reverse or slow these effects in humans