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However, several studies have shown that GLS2 is highly expressed in triple-negative basal-like breast cancer (TNBC) and metastatic lung cancer and that it confers radioresistance in advanced human cervical cancer cells, suggesting that GLS2 may reduce reactive oxygen species (ROS) levels by increasing the level of cellular reduced glutathione (GSH), NADH, or NADPH 14,15,16

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In NM_001145144 the translation starts downstream the third exon generating a shorter peptide of 313 aa

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However, sample sizes were modest, and long-term safety and efficacy data remain absent from peer-reviewed literature

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