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However, as crude as LD50 may be regarded by the purist, it is a useful guide to determine acute toxicity and is the technique currently favoured in chemical safety data sheets (section 11, Toxicology)

Bibcode:1989Natur.341..197B

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For instance, in a study by Dal Magro et al., the brain bioavailability in mice of SLNs functionalized with an ApoE-derived peptide was studied depending on the administration route of the nanoparticles

However, the study is limited because it did not assess the gut microbiota and gut health among diabetics versus healthy subjects, which is typically poor in comparison

In one study, we investigated the impact of bergamot PF extract on both 2D and 3D hepatocyte culture models, including rat cells, human hepatoma cells, and primary human hepatocytes (107)