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VacA insertion facilitates mitochondrial depolarization, swelling, and the release of pro-apoptotic factors such as apoptosis-inducing factor (AIF) and cytochrome c ( Listeria monocytogenes , an intracellular pathogen, secretes listeriolysin O (LLO), a cholesterol-dependent cytolysin that destabilizes host membranes, including mitochondrial membranes ( Staphylococcus aureus -toxin and phenol-soluble modulins perturb mitochondrial function, amplifying tissue destruction during severe infections such as pneumonia and sepsis ( 3.2 Bacterial manipulation of mitochondrial dynamics Mitochondrial fission and fusion processes, orchestrated by DRP1, MFN1/2, and OPA1, represent key checkpoints in cellular homeostasis

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Code 309.20 Best interests, as defined in the Juvenile Court Act of 1987 [705 ILCS 405], means consideration of the following factors, in the context of the childs age and developmental needs: the physical safety and welfare of the child, including food, shelter, health, and clothing

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[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Cheah I.K., Tang R.M.Y., Yew T.S.Z., Lim K.H.C., Halliwell B