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[DOI] [PubMed] [Google Scholar] 88.Hannan M.A., Dash R., Haque M.N., Mohibbullah M., Sohag A.A.M., Rahman M.A., Uddin M.J., Alam M., Moon I.S

Consistently, severe mitochondrial GSH depletion leads to increased levels of ROS and RNS, mitochondrial dysfunction and ATP depletion, converting apoptotic to necrotic cell death [32]

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When mTORC1 and mTORC2 are both inhibited using rapamycin, T cells differentiate into Treg cells (72)

These findings suggest that NFE2L2 may selectively enhance the expression of specific target genes in PDAC cells in response to activators of cuproptosis or ferroptosis