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For example, deferiprone (DFP) and PBT2 have been shown to increase endothelial tight junction protein expression in AD models, reduce vascular leakage, and improve BBB integrity, suggesting an indirect BBB-protective potential (Ayton et al., 2025)

Similarly, when compared with the cocaine-bound structure of dDAT, one of the aromatic groups of the naphthalene ring in duloxetine overlaps with the benzoyl moiety of cocaine (Supplementary Fig

Unlike therapies focused primarily on circulation, PT-141 works through pathways associated with sexual arousal and desire

After 2 h of incubation at 37 in 5% CO 2 , the absorbance at 450 nm was measured using a plate reader (200 ARVO V3

The phylogenetic distribution of cytoplasmic- or peroxisomal-localised CATs has no obvious pattern

Recent research has proposed an additional function for MDVs beyond the transportation of aberrant proteins for degradation