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Vedolizumab is currently approved by the National Institute of Health and Care Excellence (NICE) for moderate-to-severe active CD if anti-TNF treatment has failed, or if anti-TNF agents cannot be tolerated or are contraindicated[92]

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The NF-B signaling pathway, activated in 80% of RA synovium, drives cytokine production, while the Janus kinase (JAK)/signal transducers and activator of transcription (STAT) pathway mediates IL-6 signaling, contributing to chronic inflammation (11)

Ekman M, Kok P, de Lange FP (2017) Time-compressed preplay of anticipated events in human primary visual cortex

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