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It is known that amino acid metabolism, particularly via glutamine and its derivative -ketoglutarate, modulates epigenetic reprogramming during differentiation, serving as substrates for histone and DNA demethylases 17

These can include rapid heartbeat, chest pain, confusion, muscle cramps and weakness, hives, skin rashes, and difficulty breathing or swallowing [1]

Jellinger K, 1988

Regulatory effect of hsa-miR-5590-3P on TGF signaling through targeting of TGF-R1, TGF-R2, SMAD3 and SMAD4 transcripts

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks