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BMC Genomics 15:753

MMP fluorescence values were normalized to protein concentration

For example, taking high doses of vitamin C alone may not provide full protection if selenium is deficientbecause the glutathione enzymes will not function optimally

By understanding the metabolic pathway disruption and other pathophysiological determinants that dismantle ferroptosis defence, this may expose druggable targets to restore metabolic flux and recover ferroptosis defences in disease contexts

36 Finally, interfering with the metabolic conversion of glutamine to glutamate using compound 968 can also attenuate ferroptosis in some models, but the biochemical mechanism connecting glutamine to iron and/or lipid ROS remains poorly defined

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