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This inhibition attenuates the mesenchymal phenotype of BCSCs, suppresses their self-renewal capabilities, and enhances sensitivity to apoptosis, making BYL-719 a potent therapeutic agent in targeting EMT-related resistance in breast cancer [34]

Fridovich I

et al (2024) Hyperhomocysteinemia-Induced Alterations in Protein Expression and Oxidative Stress Parameters in Rat Heart

Moreover, the rupture of the blood vessel wall in hemorrhagic stroke results in the accumulation of hemoglobin and heme iron at the extracellular milieu and subsequent iron-induced LPO and ferroptosis, thereby furtherly exacerbating the stroke-induced brain injury