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Assuming an increased ROS-level and a decreased level of glutathione, especially the reduced form, as an important antioxidant in Wobbler motor neurons, it can be concluded that NAC, as a precursor of glutathione, can replenish the GSH content and thus reduce oxidative stress in Wobbler motor neurons resulting in less oxidative DNA damage

In the future, spinal cord targeting needs to be enhanced by improving drug delivery systems (such as nanocarriers or targeted modifications), optimizing dosage strategies in combination with pharmacokinetic-pharmacodynamics models, and promoting multi-stage clinical trials to clarify its clinical translational value

Activation of gasdermin D and the caspase-1/4/5/11 series distinguishes pyroptosis from other forms of death

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Jarrard D, Filon M, Huang W, Havighurst T, DeShong K, Kim K

J Diabetes Mellit 12(4):187203 Bhattacharya S, Gachhui R, Sil PC (2013) The prophylactic role of D-saccharic acid-1, 4-lactone against hyperglycemia-induced hepatic apoptosis via inhibition of both extrinsic and intrinsic pathways in diabetic rats