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Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4

Mak DH, Schober WD, Konopleva M, Cortes J, Kantarjian HM, Andreeff M , Carter BZ

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Current therapeutic strategies targeting these age-related perturbations include senolytic compounds, nutritional interventions, physical activity protocols, and heterochronic parabiosis approaches (407)

However, some of the drugs at this stage suffer from low bioavailability, insufficient targeting and poor stability, and the potential applications of these drugs need to be better understood