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Darvin P, Toor SM, Sasidharan Nair V, Elkord E

Subsequent research indicated that the enhancement of MET by activating UPF1 (a versatile RNA and DNA helicase) caused phosphorylation, which, in turn, controlled the 3'-UTR length of STING, leading to a decrease in STING expression in cancer cells [123]

A single substitution or truncation during synthesis renders the compound biologically inactive, and standard HPLC purity testing won't detect that failure