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The authors express their sincere gratitude to the Universitas Andalas Institute for Research and Community Service (LPPM) for funding this research under Contract Number: 184/UN.16.19/PT.01.03/PTM/2025 dated September 6, 2024

Finally, it is also accepted that emotional stress (see Brain Behav Immun 2009, 23, 1089-1095), tobacco smoke (see J Investig Dermatol Symp Proc 2009, 14, 53-55), air pollution, and certain medications (e.g., corticosteroids) (see Clin Exp Dermatol 1991, 16, 416-419) have an adverse effect on the skin and lead to changes (e.g., decreased formation and/or increased degradation) of collagen and other extracellular matrix components

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