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Phosphorylated STAT5B dimers translocate to the nucleus where they bind to specific DNA sequences and activate transcription of IGF-1, insulin-like growth factor binding protein-3 (IGFBP-3), and acid-labile subunit genes

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[DOI] [PubMed] [Google Scholar] 182.Goncalves-Dias C., Morello J., Semedo V., Correia M.J., Coelho N.R., Monteiro E.C., Antunes A.M.M., Pereira S.A

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Second, targeted therapies that address specific gene mutations or epigenetic changes will become crucial research directions, such as exploring the relationships between BRCA mutations and PARP inhibitor resistance

doi: 10.1080/10408398.2016.1160363, 216