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309,315 Therapies targeting endothelial function are being explored to prevent or mitigate DPN progression (Fig

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Ethics declarations Acknowledgements This work was undertaken as part of UK Biobank project application ref 56653 Pharmacogenomics to improve drug efficacy and safety

Pyridoxine Hydrochloride (a form of Vitamin B6) - essential for the maintenance of a healthy immune system and as an essential component of various metabolic pathways

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