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Pediatric Use: Safety and dosing recommendations in pediatric patients are based on published literature describing controlled studies of zinc-containing products in pediatric patients

1984 Apr;25(4):677-82

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When the tumor reached 75125 mm 3 , we randomized mice into a vehicle (25% (w/v) hydroxypropyl--cyclodextrin in 10 mmol/L citrate, pH 2) or CB-839 (200 mg/kg) with or without RT (10 Gy/fraction for three consecutive days) treatment groups

Its low molecular weight enables distribution throughout the bloodstream, reaching multiple tissues simultaneously

doi: 10.1084/jem.20050304, 17 LiL.ZhangH.Varrin-DoyerM.ZamvilS