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Studies also document TB-500's effects on basic fibroblast growth factor and vascular endothelial growth factor expression, both involved in blood vessel formation processes

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Common issues include nausea, vomiting, diarrhea, and constipation, which are typically mild to moderate and most frequent during dose escalation

Besides, the fragment crystallizable (Fc) of the antibody can bind to Fc receptors (FcRs) on the surface of immune cells and induce ADCC, making it a three-functional antibody (Triomab) [195, 196]

Taken together, it implies that the particular mutation in Tshr Df/Df rats probably regulates thyroid hormone levels in a different way which should be further studied in the future

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