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Description

These radicals initiate lipid peroxidation of PUFAs within membrane phospholipids, leading to membrane disruption and ferroptosis ( + functions as a cofactor for multiple metabolic enzymesincluding LOXs and PDH1enhancing their activity and further stimulating ROS production ( + influx, elevates ROS levels, and increases cellular sensitivity to ferroptosis

Docosahexaenoic acid (DHA), a typical -3 polyunsaturated FA, is highly enriched in oils from deep-sea fish and marine microalgae and promotes adipocyte apoptosis to combat obesity in mammals and fish (Tatsumi et al., 2022)