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As stated in, the treatment of oral squamous cell carcinoma (OSCC) with iron death inducer (PL) has been shown to result in lipid peroxidation (LPO) and intracellular ROS accumulation, accompanied by a decrease in the expression of FTH1, SLC7A11, and GPX4

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These conditions may affect the structure and function of the intestines, leading to malabsorption and nutrient deficiencies

Thus, functional characterization and analysis of regulatory aspects of gene expression of GST gene family members could help in enhancing the understanding about their role in As response and detoxification as well as evolving strategies for developing As tolerant and As-free crops through biotechnological tools in future