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Epithelial cells, the essential physical barrier between the body and the environment, are prone to damage and even death when exposed to pollutants or allergens, which subsequently promote downstream immune responses [19, 20]

Chien, Y

F., Bromer, J

In vivo, M1 macrophage exosomes with low miR-663b expression attenuated pulmonary vascular remodeling in PH rats, suggesting that exosomal miR-663b exacerbates PASMC dysfunction and PH progression by suppressing the AMPK/SIRT1 axis and promoting inflammation

Ther Adv Infectious Dis

Conversely, downregulation of ChaC2 decelerates the cell cycle progression of hESCs and triggers cell death (78), underscoring its pivotal role in regulating human growth and development