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Giurgea (who is widely accepted as being the first person to use the term Nootropic 2 ), set out a series of six characteristics that a compound must meet in order to be considered a Nootropic

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Ischemic models induce rapid oxidative damage by reperfusion-induced ROS, allowing detailed investigations into acute oxidative injury mechanisms, tissue-specific antioxidant responses, and therapeutic efficacy of antioxidants and regenerative interventions such as stem cell-derived EVs (Table 1)