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Eine Anwendung auerhalb medizinischer Studien ist daher mit Unsicherheiten verbunden

Acknowledgements The study is supported by a Singapore EDB-IPP grant (grant number: RL2012035)

This concern comes up regularly, and it is worth addressing directly

De Ita JR, Castilla-Cortzar I, Aguirre GA et al (2015) Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: an experimental approach to metabolic syndrome