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The tendency for increased t 1/2 with increasing renal impairment was not considered clinically relevant, as exposure was similar between groups, and results supported once-weekly SC administration of cagrilintide

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Karise, I., Bargut, T

Such higher deacetylated levels of Nrf2, FOXO, p53, and NF-B in the livers of these control rats may explain the parallel increase in the levels of MnSOD (SOD2), GSH, Bcl-2, and the lower activation of NF-B p65