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[RBC-P]NPs exhibit prolonged circulation and target atherosclerotic tissue in vivo [99, 100]

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For example, progressive H 2 O 2 -induced Cys oxidation leads to Cys sulfenylation (SOH), sulfinylation (SO 2 H), and sulfonylation (SO 3 H)

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Its ~5day halflife allows convenient onceweekly subcutaneous dosing [1]

Cochrane Database Syst Rev 8:CD007476 Sadrzadeh SM, Nanji AA, Price PL (1994) The oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one reduces hepatic-free iron, lipid peroxidation and fat accumulation in chronically ethanol-fed rats