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The FDA and KMFDS approved a phase III, multicenter, randomized, double-blind, sham-procedure-controlled trial, conducted exclusively in South Korea [166] NCT 04745299, KCT0005954, which did not meet primarily efficacy outcomes [167], though long-term follow-up and safety reporting continues through 2026

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Gaziano et al's large-scale trial (95) involving 14,641 male physicians found no effect of vitamin E and C on CRC incidence