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Thus, it is likely that with BPC 157 therapy, no extraosseous bone islet means the counteraction of the endochondral bone formation in extraskeletal tissues, the counteraction of vascular endothelial cells differentiation into skeletal cells, local inflammatory signals, and the release of cytokines (i.e., bone morphogenetic protein-2 and bone morphogenetic protein-4 and transforming growth factor-beta) [68]

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Zoulim F, Lenz O, Vandenbossche JJ, Talloen W, Verbinnen T, Moscalu I, Streinu-Cercel A, Bourgeois S, Buti M, Crespo J, Manuel Pascasio J, Sarrazin C, Vanwolleghem T, Shukla U, Fry J, Yogaratnam JZ

Proc Natl Acad Sci USA (2015) 112:E62156223

Moreover, oxidative stress was prominent in PR as compared to PV and were also indicated by elevated H 2 O 2 and MDA content (Table 1)

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