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doi: 10.1016/j.biochi.2013.08.022

B12 also plays a significant role in preventing vascular and cognitive diseases through its involvement in the conversion of homocysteine to methionine and then to Sadenosylmethionine

In the physiological environment, IECs secrete EVs from the apical or basolateral surfaces, and these EVs contain immunomodulatory molecules expressed on their surface, such as major histocompatibility complex (MHC)-I, MHC-II, and human leukocyte antigen-DM (HLA-DM) (Mallegol et al., 2007)