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Firstly, the further analysis of ERBB4 function in NSCLC with ICIs therapy is needed because of small clinical sample size in this research

ACF, Aberrant crypt foci

The ultrastructural organization of elastic fibers at the interface of the nucleus and annulus of the intervertebral disk

Mechanistically, deeper exploration of the spatiotemporal dynamics of strain-specific metabolic interference and how reprogramming initiates the inflammation-metaplasia-carcinoma cascade is essential, including dissecting crosstalk between mitochondrial stress (Lonp1), epigenetics (GBA1 methylation), and transcriptional regulation of metabolic enzymes