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Compared to the control group, the total effective rate in the treatment group was significantly higher ( P = .029), as shown in Table 2

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These results complement earlier studies showing anti-oxidant effect of MSM and suggest that single dose oral supplementation with MSM lowers exercise induced oxidative stress in healthy untrained young men, but is not adequate to significantly affect plasma GSH level

doi: 10.3892/ijmm.2021.4852 30

But its clinical efficacy is not ideal and glioma resistance to TMZ is the most important reason for chemotherapy failure

However, if the UPR fails to resolve the excessive buildup of unfolded proteins, it activates signaling pathways that promote inflammation and apoptosis, potentially leading to neurodegenerative disorders