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The acid resistance ability was slightly higher in in wild-type L

As in T2D, APD-induced increases in circulating insulin are hypothesized to desensitize insulin-sensitive peripheral targets (e.g., liver, skeletal muscle, adipose tissue) over time, resulting in insulin resistance and weight gain 3,4,15

N-acetylcysteine (NAC), a derivative of L-cysteine, is primarily known for its antioxidant properties, which act through direct scavenging of reactive oxygen species and enhancement of intracellular glutathione levels

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Additionally, SLC1A2 and GRM8 were found to be inhibited by BMS, while several other members, such as SLC1A3, GRM1, and GRM5, exhibited the opposite effect (Supplemental Fig