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However, a recent trial showed that besifovir dipivoxil maleate combined with L-carnitine did not lead to any improvement in hepatic steatosis in CHB patients (81)

While further studies are needed to clarify the interactions between L-serine, microbiota and the intestinal mucosa, these findings collectively underscore the potential of therapeutic strategies targeting serine metabolism, such as microbial modulation and/or specific dietary interventions, particularly in IBD and CRC

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