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V., et al

Metformin, widely prescribed for type 2 diabetes, can impair B12 absorption through effects on calcium-dependent ileal uptake

Always verify coverage with the specific payer's LCD and formulary before administering

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The compound shows high enzymatic selectivity, preserves lean mass, and engages longevity-related pathways (e.g., SIRT1), but remains a nonFDA-approved research substance that is WADA-banned and should be used under medical guidance