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The difference between in vivo and in vitro glucose metabolism implies the effect of the TME on NSCLC metabolism, even exceeding the gene phenotype (26)

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Owing to its high concentration in the cell (10 3 M) 1 , the GSH/GSSG pair acts as the main intracellular redox buffer, plays a key role in detoxification of reactive oxygen species (ROS), and participates in redox signaling 2

10.1016/j.msec.2021.111941 77 YangG.RothrauffB

Rats were maintained at 23 2 C with a 12-hour light/dark cycle and free access to food and water

The effects of 1-amino-D-proline on the production of carnitine from exogenous protein-bound trimethyllysine by the perfused rat liver