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J Mol Cell Cardiol 48:13241328

copri suspension was orally administered with a sterile sodium bicarbonate solution at a final concentration of 1.2% to protect the microbes from gastric acid damage

Menichini et al

120 Mathews S, Feng D, Maricic I, Ju C, Kumar V, Gao B

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Such TBI-induced actions, whether occurring early or later in life, can readily increase the vulnerability of the brain to other neurodegenerative events as detailed in the two hit hypothesis of the Latent Early-life Associated Regulation (LEARn) model of Lahiri et al., [92, 93], whereby genetic and environmental risk factors combine in an epigenetic pathway to trigger the etiology of a later neurobiological disorder (such as TBI leading to AD)