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Aragn IM, Imbroda BH, Lara MF

This system is orchestrated primarily by T and B lymphocytes in vertebrates, while invertebrates lack adaptive immunity

A condition in which serum vitamin B12 is normal of elevated, yet and at the same time metabolic markers pr symptoms suggest that the subject is vitamin B12 deficient Such conditions represent "Paradoxical B12 deficiency" Metabolic analysis suggests that functional deficiency in either folate or vitamin B2 is the cause of paradoxical B12 deficiency Resolution of Paradoxical deficiency requires complete resolution of functional B2 or folate deficiency Paradoxical B12 deficiency is commonly seen in conditions such as Autism Chronic Fatigue Syndrome Hypothyroidism Various malignancies Long COVID All cause mortality Persons with Paradoxical B12 deficiency are more likely to die from COVID-19 The current dogma on vitamin B12 deficiency implies a direct link between levels of serum vitamin B12, and sufficiency

5 In addition, high-intensity exercise also results in an increased production of lactic acid, which can further contribute to oxidative stress by causing a decrease in pH levels in the muscle tissues

When the body's internal environment becomes overwhelmed by reactive oxygen species and environmental stressors, a vicious cycle of inflammation and cellular exhaustion begins, leaving patients feeling poisoned by their own biology

Antibacterial and wound healing activities of micro/nanocarriers based on carboxymethyl and quaternized chitosan derivatives, in Biopolymer-based nano films (Elsevier), 191201